Endocrine Abstracts

Introduction: Immunossupression is a possible consequence of hypercortisolism, putting these patients in a state of increased risk of infections.Case report: Female, 19 years old. In July 2014 she seek for medical care because she became feverish and developed an erythematous rash on her face/trunk with subsequent widespread to the entire body. She was admitted in the ICU with the diagnosis of severe varicella with acute cholestatic hepatitis and conflue...

Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that is usually associated with metabolic disturbances such as obesity, dyslipidemia and insulin resistance. In this study, female rats treated with nonaromatizable 5α dihydrotestosterone (DHT) were used as an animal model of PCOS. The aim of this study was to assess the presence of inflammation in liver and visceral adipose tissue (VAT), which accompanies metabolic disturbances in animal model of PCOS. F...

Zoledronic acid (ZA) treatment increases bone mineral density (BMD), decreases bone turnover markers and reduces the risk of fractures in patients with osteoporosis (1).Objective: Observe and quantify the changes in BMD and bone turnover markers in postmenopausal osteoporosis (PO) patients treated annually with zoledronic acid 5 mg intravenously.Material and Methods: Medical records (MR) of PO patients whom received ZA from 2007 to...

Introduction: Fine needle biopsy (FNB) is a very important diagnostic tool in the assessment of thyroid nodules and plays a prominent role in therapeutic approach. It has a sensitivity around 83 to 85% and a specificity around 80 to 92%.Aims: To correlate cytological (FNB) and final histopathological data in patients with nodular thyroid pathology.Methods: A retrospective study of patients who underwent surgical procedure from Janu...

Introduction: Gastric endocrine tumors (GET) are rare. Type 1 tumors are non-functioning, almost exclusively benign lesions, usually presenting as multiple polyps, usually <1 cm in diameter, which arise from gastric enterochromaffin-like cells in response to chronically elevated gastrin, secondary to (auto-immune) atrophic fundic gastritis. These tumors were traditionally treated with total gastrectomy, like adenocarcinomas. Currently, surveillance or endoscopic treatment ...

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...

Introduction: Low testosterone serum levels are associated with increased mortality in non-diabetic males. However, knowledge about the association between male hypogonadism and mortality among type 2 diabetic (T2DM) men is limited due to short follow-up periods in the few existing studies.Objective: To assess the association between hypogonadism and mortality in diabetic men.Material and methods: 263 unselected men with T2DM (mean...

Introduction: The aim of our study was to evaluate the causes of thyrotoxicosis detected during pregnancy as well as to determine the prevalence of thyroid nodular disease (TND) in our population and which factors are associated with this condition.Methods: We performed a retrospective review of 1,760 patients between April 2014 and September 2017 remitted from the gynecology department due to thyroid dysfunction detected in the 9th week of pr...